Makes an attempt to find a breakthrough dementia drug may be drawing consideration today, however conventional medicinal merchandise can supply hints for preventive medication.
A analysis group led by Specifically Appointed Professor Takami Tomiyama of Osaka Metropolitan College’s Graduate Faculty of Medication has discovered that administering the dried seeds of a kind of jujube known as Ziziphus jujuba Miller var. spinosa, used as a medicinal herb in conventional Chinese language medication, holds promise in restoring cognitive and motor perform in mannequin mice.
By administering sizzling water extracts of Zizyphi spinosi semen to mannequin mice with Alzheimer’s illness, frontotemporal dementia, Parkinson’s illness, and dementia with Lewy our bodies, the staff discovered that cognitive and motor features have been restored.
Moreover, when the seeds have been merely crushed into powder and administered to the mannequin mice, the staff found that the cognitive perform of the mannequin mice recovered to a degree above that of management mice. As well as, the powders apparently suppressed mobile getting old in older mice and improved their cognitive perform to an identical degree as youthful mice.
Beforehand, members of the analysis staff reported individually that the pathology of dementia in mannequin mice improved with cognitive and motor features restored after utilizing the Hawaiian herb mamaki and the Chinese language herb Acorus gramineus.
The outcomes of our analysis will hopefully make it attainable to develop dementia prevention merchandise that middle-aged and aged individuals can take at their very own discretion.”
Takami Tomiyama, Professor, Graduate Faculty of Medication, Osaka Metropolitan College
The findings are at present accessible as a reviewed preprint in eLife.
Supply:
Journal reference:
Umeda, T., et al. (2024) Merely crushed Zizyphi spinosi semen prevents neurodegenerative ailments and reverses age-related cognitive decline in mice. doi.org/10.7554/elife.100737.1.
