NASA Spaceline Present Consciousness Record — Grok through Astrobiology.com
SPACELINE Present Consciousness Lists are distributed through listserv and can be found on the NASA Process E book web site at https://taskbook.nasaprs.com/Publication/spaceline.cfm. Please ship any correspondence or request to unsubscribe to Shawna Byrd, SPACELINE Present Consciousness Senior Editor, [email protected].
Name for articles to quote within the weekly lists: Authors at NASA Facilities and NASA PIs—do you could have an article that has not too long ago revealed or will publish within the upcoming weeks inside a peer-reviewed journal and is within the scope of house life sciences? If that’s the case, ship it our means! Ship your article to the e-mail tackle talked about above. Articles obtained by Wednesday will seem inside that week’s record—articles obtained after Wednesday will seem the next week.
Papers deriving from NASA assist:
1
Moestl S, De Boni L, Hoenemann J-N, Kramer T, Schmitz J, Pesta D, Frett T, Bohmeier M, Frings-Meuthen P, Ewald AC, Nitsche A, Loehr P, Noppe A, Klischies N, Huang AS, Laurie SS, Marshall-Goebel Okay, Macias BR, Tank J, Jordan J, Mulder E.
Mechanical countermeasures for spaceflight-associated neuro-ocular syndrome throughout 30-days of head-down tilt bedrest: Design, implementation, and tolerability.
Entrance Physiol. 2025 Feb 23;16:1530783.
https://doi.org/10.3389/fphys.2025.1530783
Notice: From the summary: “After longer length house missions, some astronauts expertise structural and practical modifications within the eye and structural modifications within the mind, termed Spaceflight-Related Neuro-Ocular Syndrome (SANS). Countermeasures towards SANS are required to attenuate potential operation impacts and damaging long-term well being penalties. Headward fluid shifts, which seem to advertise SANS, present a goal for countermeasures. The SANS countermeasures research, a 30 days strict head-down tilt bedrest (HDTBR) research, examined two mechanical countermeasures geared toward reversing cephalad fluid overload. This work presents design and methodology of the research with a concentrate on countermeasure implementation and tolerability.” This text could also be obtained on-line with out cost.
Journal Influence Issue: 3.2
Funding: S.S. Laurie, Okay. Marshall-Goebel, and B.R. Macias are affiliated with NASA Johnson Area Heart.
2
Nguyen T, Ong J, Brunstetter T, Gibson CR, Macias BR, Laurie S, Mader T, Hargens A, Buckey JC, Lan M, Wostyn P, Kadipasaoglu C, Smith SM, Zwart SR, Frankfort BJ, Aman S, Scott JM, Waisberg E, Malsalkhi M, Lee AG.
Spaceflight related neuro-ocular syndrome (SANS) and its countermeasures.
Prog Retin Eye Res. 2025 Feb 17;101340. Evaluation.
https://pubmed.ncbi.nlm.nih.gov/39971096
Notice: From the summary: “This evaluation examines the potential causes and countermeasures of SANS, together with house anticipation glasses, decrease physique damaging stress, venous thigh cuffs, impedance threshold gadgets, translaminar stress gradient modulation, centrifugation, synthetic gravity, prescription drugs, and precision dietary supplementation. This paper highlights future analysis instructions for understanding the genetic, anthropometric, behavioral, and environmental susceptibilities to SANS in addition to easy methods to use terrestrial analogs for testing future mitigation methods.”
Journal Influence Issue: 18.7
Funding: T. Brunstetter, B.R. Macias, S. Laurie, and S.M. Smith are affiliated with NASA Johnson Area Heart.
3
Johnston SL, Jones JA, Johnston ST.
Chapter 20 – Classes discovered half II: In-flight medical tools, capabilities, and countermeasures; and new medical paradigms for the longer term flights to low Earth orbit and past!
In: Schmidt MA, Legato MJ, eds. Constructing a Area-Faring Civilization: Advancing the Renaissance of Science, Drugs, and Human Efficiency in Civilian Spaceflight. London: Tutorial Press, 2025. p. 279-301.
https://doi.org/10.1016/B978-0-443-13850-8.00025-7
Notice: Extra details about not too long ago revealed guide “Constructing a Area-Faring Civilization: Advancing the Renaissance of Science, Drugs, and Human Efficiency in Civilian Spaceflight” is obtainable at https://doi.org/10.1016/C2022-0-02900-7.
Funding: S.L. Johnston is affiliated with NASA Johnson Area Heart.
4
Duporge I, Pereira T, Castiello de Obeso S, Vibrant Ross JG, Lee SJ, Hindle AG.
The utility of animal fashions to tell the subsequent era of human house exploration.
npj Microgravity. 2025 Feb 22;11:7. Evaluation.
https://pubmed.ncbi.nlm.nih.gov/39984492
PI: T. Pereira
Notice: This text could also be obtained on-line with out cost.
Journal Influence Issue: 5.1
Funding: “ID thanks Centre nationwide d’études spatiales (CNES) of the French Ministries of Defence and Analysis for the grant to attend the Worldwide Area Research Program on the Nationwide Institute for Area Analysis (INPE) & the Aeronautics Institute of Know-how (ITA) in São José dos Campos, Brazil. This Program was held with the assist of the Brazilian Area Company (AEB). This grant supported the creation of this work and the undertaking was supported partially by an appointment to the NRC Analysis Associateship Program at the US Military Analysis Laboratory administered by the Fellowships Workplace of the Nationwide Academies of Sciences, Engineering, and Drugs. The paper define stems from the Human Efficiency in Area division of the Area Research Program organized by Chief Science Officer underneath the Human Well being and Efficiency (HH&P) Directorate on the NASA Johnson Area Heart. TP was supported by NASA HRP (80NSSC24K0346).”
5
Liu J, Perren JO, Rogers CM, Nimer S, Wen AX, Halliday JA, Fitzgerald DM, Mei Q, Nehring RB, Crum M, Kozmin SG, Xia J, Cooke MB, Zhai Y, Bates D, Li L, Hastings PJ, Artsimovitch I, Herman C, Sung PM, Miller KM, Rosenberg SM.
Endogenous DNA injury at websites of terminated transcripts.
Nature. 2025 Feb 19.
https://pubmed.ncbi.nlm.nih.gov/39972147
PI: S.M. Rosenberg
Journal Influence Issue: 50.5
Funding: “The research was supported by the W. M. Keck Basis (S.M.R. and Okay.M.M.), Nationwide Institutes of Well being (NIH) Director’s Pioneer Awards DP1-AG072751 (S.M.R.) and DP1-AI152073 (C.H.), NIH grants R01-CA250905 (S.M.R. and Okay.M.M.), R35-CA241801 (P.M.S.), R01-GM067153 (I.A.), R01-GM106373 (P.J.H.), R01-GM135368 (D.B.) and R00ES033259 (J.X.); Nationwide Aeronautics and Area Administration, Translational Well being Analysis Institute grant NNX16AO69A (S.M.R. and Okay.M.M.), American Most cancers Society Postdoctoral Fellowships PF-18-035-01 (D.M.F.) and PF-22-034-01-DMC (C.M.R.); the Dan L Duncan Complete Most cancers Heart NIH P30-CA125123, and its assist of the Baylor School of Drugs (BCM) Built-in Microscopy Core and the Heart for Superior Microscopy and Picture Informatics (additionally CAMII, NIH DK56338 and ES030285) and BCM Cytometry and Cell Sorting core (additionally NIH P30-AI36211 and S10-RR024574; Most cancers Prevention and Analysis Institute of Texas RP150578 and RP170719), and the John S. Dunn Gulf Coast Consortium for Chemical Genomics.”
6
McCann H, Meade CD, Williams LD, Petrov AS, Johnson PZ, Simon AE, Hoksza D, Nawrocki EP, Chan PP, Lowe TM, Ribas CE, Sweeney BA, Madeira F, Anyango S, Appasamy SD, Deshpande M, Varadi M, Velankar S, Zirbel CL, Naiden A, Jossinet F, Petrov AI.
R2DT: A complete platform for visualizing RNA secondary construction.
Nucleic Acids Res. 2025 Feb 8;53(4):gkaf032.
https://pubmed.ncbi.nlm.nih.gov/39970282
Notice: This text could also be obtained on-line with out cost.
Journal Influence Issue: 16.7
Funding: “B.S. and C.R. had been supported by WT grant (218302/Z/19/Z) and EMBL core funds. M.D. was supported by WT grant (218303/Z/19/Z). S.D.A. was supported by WT grant (221327/Z/20/Z). M.V. was supported by WT grant (223739/Z/21/Z). S.A. and S.V. had been supported by EMBL core funds. P.C. and T.L. had been supported by NIH/NHGRI award R01HG006753 and NSF award 2022065. L.D.W. and A.S.P. had been supported by NASA grant 80NSSC24K0344. …
“
__________________________________________________
Different papers of curiosity:
1
Wostyn P, Nedergaard M.
Might sleep be an antidote to optic disc edema in astronauts?
Life (Basel). 2025 Jan 26;15(2):183.
https://doi.org/10.3390/life15020183
Notice: This text is a perspective and a part of Particular Concern “Area Drugs Ophthalmology: Insights from Molecular Observations to the Medical Administration of Ocular Dangers in Microgravity” (https://www.mdpi.com/journal/life/special_issues/416F742D6M). The Particular Concern additionally consists of an article from earlier Present Consciousness Record #1,132 https://doi.org/10.3390/life14121598. Further articles will likely be forthcoming and could also be discovered within the hyperlink to the Particular Concern. This text could also be obtained on-line with out cost.
2
Kuznetsov NV, Statsenko Y, Ljubisavljevic M.
An replace on neuroaging on Earth and in spaceflight.
Int J Mol Sci. 2025 Feb 18;26(4):1738. Evaluation.
https://doi.org/10.3390/ijms26041738
Notice: From the summary: “Over 400 articles on the pathophysiology of mind ageing, neuroaging, and neurodegeneration had been reviewed, with a concentrate on epigenetic mechanisms and quite a few non-coding RNAs. Particularly, this evaluation the accent is on microRNAs, the invention of whose pivotal position in gene regulation was acknowledged by the 2024 Nobel Prize in Physiology or Drugs. Ageing just isn’t a gradual course of that may be simply modeled and described. As a substitute, a number of temporal processes happen throughout ageing, they usually can result in mosaic modifications that aren’t uniform in tempo.” This text is a part of Particular Concern “Breakthroughs in Diagnostic Prediction and Basic Therapeutics of Dementia and Motion Problems, 2nd Version” (https://www.mdpi.com/journal/ijms/special_issues/69G2PJV2Y9) and could also be obtained on-line with out cost.
3
Buckey JC, Lan M.
Touch upon: “A multifactorial, evidence-based evaluation of pathophysiology in spaceflight related neuro-ocular syndrome (SANS).”
Eye (Lond). 2025 Feb 23.
https://pubmed.ncbi.nlm.nih.gov/39988633
Notice: It is a touch upon an article that appeared in Present Consciousness record #1,133 https://doi.org/10.1038/s41433-025-03618-3.
4
Ghosh N, Garg I, Srivastava S.
Microgravity as a contributing issue to venous thromboembolism improvement: Dangers and prevention methods.
Life Sci Area Res. 2025 Feb 22. Evaluation. On-line forward of print.
https://doi.org/10.1016/j.lssr.2025.02.008
5
Hou H, Qiu Z, Che J, Li Y, Solar J, Zhang W, Ma J, Zhang S, Li M, Niu Y, He L.
Results of simulated microgravity on dental pulp stem cell stemness.
J Mol Histol. 2025 Feb 26;56(2):97.
https://pubmed.ncbi.nlm.nih.gov/40011255
Notice: A 3D clinostat was used on this research.
6
Schulz H, Abdelfattah F, Heinrich A, Melnik D, Sandt V, Krüger M, Wehland M, Hoffmann P, Cortés-Sánchez JL, Evert M, Evert Okay, Grimm D.
Omics investigations of prostate most cancers cells uncovered to simulated microgravity situations.
Biomolecules. 2025 Feb 18;15(2):303.
https://doi.org/10.3390/biom15020303
Notice: A random positioning machine was used on this research. This text is a part of Particular Concern “Omics Information Integration: Specializing in Molecular Biomarkers for Cancers and Illnesses” (https://www.mdpi.com/journal/biomolecules/special_issues/460U7YOA92) and could also be obtained on-line with out cost.
7
Wang Y, Chen T, Shi Z, Dong L, Li M, Peng B, Li Q, Pan R, Xiao S, Yang Q, Jiang N, Liu X, Hu Q, Chen Y.
Ginsenoside reshapes intestinal microecology to alleviate microgravity stress.
Drug Des Devel Ther. 2025 Feb 24;19:1289-303.
https://doi.org/10.2147/DDDT.S486371
Notice: This text could also be obtained on-line with out cost.
8
Zhang X, Zhu H, Zhang J.
Oxidative stress on the bottom and within the microgravity atmosphere: Pathophysiological results and therapy.
Antioxidants. 2025 Feb 18;14(2):231. Evaluation.
https://doi.org/10.3390/antiox14020231
Notice: This text could also be obtained on-line with out cost.
9
Zhang Y, Wang S, Chen J, Zhou Y, Yu X, Peng R, Lu L, Li S, Tian Z, Zhang N, Yang H.
Augmentation of antiviral immune response induced by perturbation of CD82 underneath microgravity situation.
Fish Shellfish Immunol. 2025 Feb 20:110216.
https://pubmed.ncbi.nlm.nih.gov/39986582
10
Bailey DM.
Decoding the house integrome: Customized countermeasures for a mission to Mars.
Exp Physiol. 2025 Feb 21. On-line forward of print.
https://pubmed.ncbi.nlm.nih.gov/39982176
Notice: This text could also be obtained on-line with out cost.
11
Peate I.
The Musculoskeletal System.
United Kingdom: John Wiley & Sons, Ltd., 2025. 167 p.
https://www.wiley.com/en-us/The+Musculoskeletal+System-p-9781394252602
12
Wang J, Li S, Li Q, Yan Q, Wang Y, Zeng X, Yang F, Jiang S, Zhang M, Pi Y, Tahir R, Wei L.
Alda-1 mediates cell senescence and counteracts bone loss in weightlessness via regulating mitophagy.
Life Sci. 2025 Feb 19;366-367:123482.
https://pubmed.ncbi.nlm.nih.gov/39983821
Notice: 2D-rotating wall vessel bioreactor and hindlimb unloading research.
13
Wang Y, Dong D, Zhou W, He J.
Versatile wearable machine purposes for monitoring astronaut well being: Present standing and challenges.
Wearable Electronics. 2025 Feb 18. Evaluation. On-line forward of print.
https://doi.org/10.1016/j.wees.2024.12.007
14
McCrum C, Zhu M, Willems P, Visser I, Kastrinou M, van de Berg R, Meijer Okay, Hallemans A, Herssens N.
Assessing gait variability concurrently with dynamic visible acuity on a treadmill in folks with bilateral vestibulopathy.
J Vestib Res. 2025 Jan 10:9574271251313806.
https://pubmed.ncbi.nlm.nih.gov/39973592
Notice: This text could also be obtained on-line with out cost.
15
Zang P, Chen P, Chen J, Solar J, Lan H, Dong H, Liu W, Xu N, Wang W, Hou L, Solar B, Zhang L, Huang J, Wang P, Ren F, Liu S.
Alteration of gastrointestinal operate and the ameliorative results of Hericium erinaceus polysaccharides in tail suspension rats.
Vitamins. 2025 Feb 18;17(4):724.
https://doi.org/10.3390/nu17040724
Notice: This text is a part of Part “Phytochemicals and Human Well being” (https://www.mdpi.com/journal/nutrients/sections/Phytochemicals_Human_Health) and could also be obtained on-line with out cost.
16
Dey A, Jagadanandan J.
Unveiling the realm of AI governance in outer house and its significance in nationwide house coverage.
Acta Astronaut. 2025 Mar;228:253-64.
https://doi.org/10.1016/j.actaastro.2024.11.022
Notice: From the summary: “This text explores the notable authorized considerations that will come up from the rising utilization of synthetic intelligence and machine studying in outer house. Whether or not it’s conducting house exploration, clearing orbital particles, or extracting sources from particular areas in house, these actions are gaining popularity. Due to this fact, it’s crucial to ascertain a regulatory framework to make sure consistency and goal requirements.”
astrobiology, house biology, house drugs, microgravity,
